US infectious disease chief Dr Anthony Fauci says the nation has a "serious problem" as 16 states reel from a spike in Covid-19 cases.
At the first White House task force briefing in two months, Dr Fauci said: "The only way we're going to end it is by ending it together."
As health experts said more must be done to slow the spread, Vice-President Mike Pence praised US "progress".
More than 40,000 new cases were recorded across the US on Friday
The total of 40,173, given by Johns Hopkins University, was the highest daily total so far, exceeding the record set only the previous day.
There are over 2.4 million confirmed infections and more than 125,000 deaths nationwide - more than any other country.
During Friday's briefing, the White House task force also urged millennials to get tested, even if they are asymptomatic.
Mr Pence said the president requested the task force address the American people amid surges in infections and hospital admissions across southern and western states.
In Texas, Florida and Arizona, reopening plans have been paused due to the spike.
While some of the increase in daily cases recorded can be attributed to expanded testing, the rate of positive tests in some areas is also increasing.
Health officials in the US estimate the true number of cases is likely to be 10 times higher than the reported figure.
What was said at the White House briefing?
Dr Deborah Birx, coronavirus response coordinator, thanked younger Americans for heeding official guidance on testing.
"Whereas before we told them to stay home, now we are telling them to get tested."
She noted this "great change" in testing guidance would allow officials to find "the asymptomatic and mild diseases that we couldn't find before".
Following Dr Birx's presentation of the recent data, Dr Fauci said: "As you can see we are facing a serious problem in certain areas."
He added: "So what goes on in one area of the country ultimately could have an affect on other areas."
Dr Fauci said the current rises were due to everything from regions "maybe opening a little bit too early", to opening at a reasonable time "but not actually following steps in an orderly fashion", to the citizens themselves not following guidance.
"People are infecting other people, and then ultimately you will infect someone who's vulnerable," he said.
"You have an individual responsibility to yourself, but you have a societal responsibility because if we want to end this outbreak, really end it... we've got to realise that we are part of the process."
Dr Fauci added that if the spread was not stopped, eventually even the parts of the country doing well now would be affected.
The vice-president, meanwhile, praised the nation's headway in handling the pandemic, noting "extraordinary progress" in former virus hotspots, like New York and New Jersey.
"We slowed the spread, we flattened the curve, we saved lives," he said.
Mr Pence also appeared to deny any link between states reopening and the increase in cases.
Responding to a reporter's question, he said the southern states that have reopened did so months ago, when new cases and rates were low.
Mr Pence instead blamed much of the rise on positive test results from asymptomatic young people, adding that while they may be at lower risk of serious symptoms, they should "take countermeasures" and listen to state governors' advice. BBC